Molecular Surveillance of Malaria (MMS) is an essential component of public health strategies aimed at controlling and eliminating malaria, particularly in endemic regions. It involves the systematic collection and analysis of molecular data to monitor the prevalence of malaria parasites, assess drug resistance, and understand transmission dynamics.
K13 mutations in Plasmodium falciparum, particularly the R561H allele, have emerged as significant markers of artemisinin resistance in Rwanda. These mutations are associated with delayed parasite clearance following treatment with artemisinin-based combination therapies (ACTs), notably artemether-lumefantrine. he distribution of K13 mutations has been found to be spatially clustered, particularly in high-transmission areas of southeastern Rwanda. This geographic clustering raises concerns about localized outbreaks of resistant malaria strains. Therefore, there is a need to conduct regular surveillance of the resistance of malaria parasites to currently used anti-malaria drugs.
The role of a specialist in MMS encompasses various responsibilities, including data collection, analysis, and the application of genomic techniques to enhance surveillance efforts. The Malaria Molecular Surveillance Specialist will support the MOPDD/RBC in strengthening malaria molecular surveillance across Rwanda by overseeing laboratory surveillance activities and building laboratory capacity. This role is essential in malaria parasite and vector surveillance, particularly in response to emerging anti-malaria drug resistance and mosquito insecticide resistance. The individual will lead advanced molecular analysis, including PCR, sequencing, and other malaria diagnostics, train NRL and selected lab network staff on molecular techniques, and enhance diagnostic capabilities to improve response and mitigation efforts against malaria threats. This document outlines the essential terms of reference for a specialist in malaria molecular surveillance.
Reporting Structure:
Title: Malaria Molecular Surveillance Specialist
Grade: 8
Department/Project: RISE Project Location: Kigali, RBC
Position Reports To: Malaria Senior Advisor/USAID Tubeho Project
Positions Supervised: None
Duration: Time of the project
Jhpiego Expectations:
All staff members of Jhpiego, regardless of the level of their responsibilities are expected to:
- Model the mission and values of Jhpiego.
- Participate in the business development process.
- Contribute to the knowledge sharing and transfer process.
- Make responsible decisions that result in time and cost containment and clear accountability.
- Adhere to the Jhpiego code of conduct, policies and procedures.
1. Data Colection and Analysis:
• Design and implement sampling strategies to collect Plasmodium falciparum samples, ensuring alignment with public health priorities.
• Analyze genetic data to detect mutations associated with drug resistance, particularly focusing on K13 mutations, pfmdr, pfhrp2/3 deletions and other relevant markers.
2. Monitoring Transmission Dynamics:
• Characterize malaria transmission sources and dynamics through genomic data analysis.
• Utilize genetic diversity metrics to estimate local transmission intensity and identify outbreaks versus sustained transmission.\
3. Methodological Development:
• Establish standardized protocols for MMS, including sample size calculations and epidemiological considerations.
• Collaborate with stakeholders to enhance the quality of data collected through molecular techniques.
4. Malaria Molecular Surveillance
• Conduct and lead malaria molecular analysis with high proficiency, including PCR (Polymerase Chain Reaction), sequencing, and genotyping.
• Develop an annual or periodic procurement plan for reagents, commodities, and other supplies required for malaria molecular analysis.
• Support vector and parasite surveillance activities in designated malaria sentinel sites, ensuring accurate and timely data collection.
• Analyse and provide periodic reports on molecular surveillance to the NRL and MOPDD/RBC.
5. Capacity Building and Training
• Develop and deliver specialized training programs for laboratory technicians on malaria molecular analysis techniques and surveillance methodologies.
• Mentor laboratory staff on molecular analysis and data management to enhance decentralized malaria surveillance at the sub-national level.
• Facilitate workshops and seminars to disseminate knowledge on the importance of MMS in malaria control.
6. Collaboration and Coordination
• Provide technical support to RBC/MOPDD and NRL staff to integrate laboratory findings by integrating molecular data into routine surveillance systems for a comprehensive malaria monitoring system.
• Assist in developing tools for real-time tracking of biological threats that may affect intervention efficacy.
• Collaborate with public health teams to support evidence-based interventions aimed at reducing malaria transmission and mitigating resistance.
• Participate in program planning and provide technical input to support the division's strategic goals.
7. Laboratory Management and Quality Assurance
• Implement quality control measures for molecular determinations, ensuring accuracy and reliability of results.
• Maintain accurate records, documentation, and reporting for all surveillance including TES laboratory analyses and training sessions.
• Ensure NRL participates in external quality assessment schemes to maintain high standards in malaria laboratory practices.
Expected Outcomes
By fulfilling these terms of reference, the specialist will contribute to:
• Enhanced understanding of malaria transmission dynamics through genomic insights.
• Improved decision-making capabilities for RBC/MOPDD and NRL based on robust molecular surveillance data.
• Strengthened capacity for early detection of drug resistance and transmission sources, ultimately aiding in malaria elimination efforts.
Education:
• Required: Master’s Degree (MSc) in Biomedical Laboratory Sciences, Molecular Biology, Microbiology, or a related fields.
• Preferred: PhD in Biomedical Laboratory Sciences, Molecular Biology, Microbiology, or a related field.
• Experience: 5-10 years of laboratory experience, with demonstrated proficiency in malaria molecular analysis, including PCR, sequencing, genotyping, and microscopy.
• Publications: To have published at least two peer-reviewed papers related to the molecular characterization of Malaria parasites.
Skills:
o Strong expertise in molecular biology techniques, particularly PCR, sequencing, and genotyping, with an emphasis on malaria diagnostics.
o Strong commitment to capacity building and training in malaria, with a proven record.
o Excellent interpersonal skills and ability to work collaboratively within a team setting.
• Additional Requirements: Knowledge of malaria transmission dynamics, anti-malarial drug resistance, and insecticide resistance is highly desirable.
Key Competencies:
• Analytical Skills: High proficiency in complex molecular and microscopy analyses and interpretation of results to guide malaria surveillance and response efforts.
• Communication: Strong verbal and written communication skills, with the ability to produce detailed reports and training materials.
• Problem-Solving: Proactive in identifying solutions to improve laboratory workflows and address technical challenges.
Languange proficiency:
- The candidate should be fluent in English.
Benefits:
• Contribute to a nationally significant program in malaria surveillance and resistance monitoring.
• Opportunities for professional development and participation in potential specialized training.
#LI-CM8
Application submission deadline: 31st December 2024.
The position is on a national contract and only Rwandan are encouraged to apply.
Jhpiego offers competitive salaries and a comprehensive employee benefits package.
Please apply at www.jhpiego.org/careers (icims.com)
Applicants must submit a single document for upload to include: cover letter, resume, and references.
For further information about Jhpiego, visit our website at www.jhpiego.org
Note: The successful candidate selected for this position will be subject to a pre-employment background investigation.
Jhpiego is an Affirmative Action/Equal Opportunity Employer
Jhpiego, a Johns Hopkins University affiliate, is an equal opportunity employer and does not discriminate on the basis of gender, marital status, pregnancy, race, color, ethnicity, national origin, age, disability, religion, sexual orientation, gender identity or expression, veteran status, other legally protected characteristics or any other occupationally irrelevant criteria. Jhpiego promotes Affirmative Action for minorities, women, individuals who are disabled, and veterans.
Jhpiego has become aware of scams involving false job offers. Please be advised:
Software Powered by iCIMS
www.icims.com